Despite the thrills and shocks served up by the likes of Lincoln, Sutton and Millwall, four of the Premier League's current top five are left in the competition.
The clubs boast 32 FA Cup wins between them, with Arsenal leading the way with 12.
Chelsea and Spurs met at the same stage in 2012 when the Blues ran out 5-1 winners through goals from Didier Drogba, Juan Mata, Ramires, Frank Lampard and Florent Malouda.
Amazingly, Arsenal and City have met just twice before at any stage in the competition, the most recent of which was a 2-1 fifth-round win for the Gunners in 1971.
The matches will be played over the weekend of April 22-23, with the final on Saturday, May 27.
Ties to be played April 22-23:
